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A few cases of breast cancers exhibited strong cytoplasmic immunoreactivity. Several cases of cholangiocarcinomas, prostate and pancreatic cancers showed weak to moderate cytoplasmic positivity. Nuclear membranous positivity was observed in a few hepatocellular carcinomas. Remaining malignant cells were mainly negative.
GENE INFORMATION
Gene name
SLC18A3 (HGNC Symbol)
Synonyms
VACHT
Description
Solute carrier family 18 (vesicular acetylcholine transporter), member 3 (HGNC Symbol)
Entrez gene summary
This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
