Expression of GABRD in cancer - Summary

CANCER ATLAS

Gene description

Gamma-aminobutyric acid (GABA) A receptor, delta

Protein class

Disease related genes, FDA approved drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044371

GENE INFORMATION
Gene name	GABRD
Synonyms
Description	Gamma-aminobutyric acid (GABA) A receptor, delta (HGNC Symbol)
Entrez gene summary	Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	2019324 - 2030751
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187730 (version 83.38)
Entrez gene	2563
UniProt	O14764 (UniProt - Evidence at protein level)
neXtProt	NX_O14764
Antibodypedia	GABRD antibodies

PROTEIN BROWSER

GABRD-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GABRD-001 ENSP00000367848 ENST00000378585	O14764 [Direct mapping] Gamma-aminobutyric acid receptor subunit delta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0034707 [chloride channel complex] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:1902476 [chloride transmembrane transport] GO:1902711 [GABA-A receptor complex] Show all	452 aa 50.7 kDa	Yes	4