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CARD9

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GENERAL INFORMATION

Gene name

 CARD9

Gene description

 Caspase recruitment domain family, member 9

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HMC-1, NB-4, THP-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, NB-4, THP-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CARD9

Synonyms

Description

 Caspase recruitment domain family, member 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 136361903 - 136373681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187796 (version 83.38)

Entrez gene

 64170

UniProt

 Q9H257 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H257

Antibodypedia

 CARD9 antibodies

PROTEIN BROWSER
CARD9-001
CARD9-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CARD9-001
ENSP00000360799
ENST00000371734
Q9H257 [Direct mapping]
Caspase recruitment domain-containing protein 9
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0046330 [positive regulation of JNK cascade]
GO:0050700 [CARD domain binding]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
Show all
 492 aa
56.7 kDa 		No 0
CARD9-004
ENSP00000360797
ENST00000371732
Q9H257 [Direct mapping]
Caspase recruitment domain-containing protein 9
A0A024R8F1 [Target identity:100%; Query identity:100%]
Caspase recruitment domain family, member 9, isoform CRA_b
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0009620 [response to fungus]
GO:0019904 [protein domain specific binding]
GO:0032494 [response to peptidoglycan]
GO:0032495 [response to muramyl dipeptide]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042493 [response to drug]
GO:0042534 [regulation of tumor necrosis factor biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043330 [response to exogenous dsRNA]
GO:0045076 [regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0045408 [regulation of interleukin-6 biosynthetic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0050700 [CARD domain binding]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051607 [defense response to virus]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
Show all
 536 aa
62.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.