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DMBT1

CANCER ATLAS

Gene description

 Deleted in malignant brain tumors 1

Protein class

 Disease related genes, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040778

GENE INFORMATION

Gene name

 DMBT1 (HGNC Symbol)

Synonyms

 GP340, muclin

Description

 Deleted in malignant brain tumors 1 (HGNC Symbol)

Entrez gene summary

 Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Nov 2014]

Chromosome

 10

Cytoband

 q26.13

Chromosome location (bp)

 122560665 - 122643736

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187908 (version 83.38)

Entrez gene

 1755

UniProt

 Q9UGM3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UGM3

Antibodypedia

 DMBT1 antibodies

PROTEIN BROWSER
DMBT1-001
DMBT1-002
DMBT1-003
DMBT1-201
DMBT1-202
DMBT1-203
DMBT1-204
DMBT1-205

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMBT1-001
ENSP00000342210
ENST00000338354
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 2413 aa
260.7 kDa 		Yes 0
DMBT1-002
ENSP00000343175
ENST00000344338
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 2403 aa
259.7 kDa 		Yes 0
DMBT1-003
ENSP00000327747
ENST00000330163
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 1785 aa
194 kDa 		Yes 0
DMBT1-201
ENSP00000352593
ENST00000359586
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 1133 aa
124.5 kDa 		Yes 0
DMBT1-202
ENSP00000357905
ENST00000368909
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001824 [blastocyst development]
GO:0001833 [inner cell mass cell proliferation]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0030858 [positive regulation of epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 2413 aa
260.7 kDa 		Yes 0
DMBT1-203
ENSP00000357951
ENST00000368955
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 2403 aa
259.7 kDa 		Yes 0
DMBT1-204
ENSP00000357952
ENST00000368956
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 1785 aa
194 kDa 		Yes 0
DMBT1-205
ENSP00000484603
ENST00000619379
Q9UGM3 [Direct mapping]
Deleted in malignant brain tumors 1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006898 [receptor-mediated endocytosis]
GO:0008329 [signaling pattern recognition receptor activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019898 [extrinsic component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030855 [epithelial cell differentiation]
GO:0035375 [zymogen binding]
GO:0042589 [zymogen granule membrane]
GO:0043152 [induction of bacterial agglutination]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
Show all
 2413 aa
260.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.