Cell atlas - COL4A5 - The Human Protein Atlas

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COL4A5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Lipid droplets

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	COL4A5
Gene description	Collagen, type IV, alpha 5
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the lipid droplets.
RNA cell category	Cell line enhanced (HUVEC TERT2, TIME, SiHa)
Protein evidence	Evidence at protein level
Main location	Localized to the Lipid droplets (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA065449
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, TIME, SiHa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the lipid droplets.

Main location

Lipid droplets (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065449	HeLa	Lipid droplets
	HPA065449	SiHa	Lipid droplets
	HPA065449	U-2 OS	Lipid droplets

GENE INFORMATION
Gene name	COL4A5 (HGNC Symbol)
Synonyms	ASLN, ATS
Description	Collagen, type IV, alpha 5 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	108439844 - 108697545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188153 (version 83.38)
Entrez gene	1287
UniProt	P29400 (UniProt - Evidence at protein level)
neXtProt	NX_P29400
Antibodypedia	COL4A5 antibodies

PROTEIN BROWSER

COL4A5-001	COL4A5-006	COL4A5-009	COL4A5-010	COL4A5-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL4A5-001 ENSP00000354505 ENST00000361603	P29400 [Direct mapping] Collagen alpha-5(IV) chain Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0007411 [axon guidance] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] Show all	1685 aa 161 kDa	Yes	0
COL4A5-006 ENSP00000331902 ENST00000328300	P29400 [Direct mapping] Collagen alpha-5(IV) chain Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005587 [collagen type IV trimer] GO:0005604 [basement membrane] GO:0005605 [basal lamina] GO:0005788 [endoplasmic reticulum lumen] GO:0007411 [axon guidance] GO:0007528 [neuromuscular junction development] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031594 [neuromuscular junction] Show all	1691 aa 161.6 kDa	Yes	0
COL4A5-009 ENSP00000423520 ENST00000515658	H0Y998 [Direct mapping] Collagen alpha-5(IV) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005581 [collagen trimer] Show all	115 aa 11.5 kDa	No	0
COL4A5-010 ENSP00000424845 ENST00000504541	H0Y9R8 [Direct mapping] Collagen alpha-5(IV) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005581 [collagen trimer] Show all	73 aa 8.3 kDa	No	0
COL4A5-011 ENSP00000424137 ENST00000505728	H0Y9H0 [Direct mapping] Collagen alpha-5(IV) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		174 aa 16.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.