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Most cancer tissues showed weak to moderate positivity. Basal cell carcinomas, liver and colorectal cancer showed cases with strong immunoreactivity.
GENE INFORMATION
Gene name
PRKAR1B
Synonyms
Description
Protein kinase, cAMP-dependent, regulatory, type I, beta (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
C9JSK5 [Direct mapping] cAMP-dependent protein kinase type I-beta regulatory subunit
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0001932 [regulation of protein phosphorylation] GO:0005952 [cAMP-dependent protein kinase complex] GO:0008603 [cAMP-dependent protein kinase regulator activity]