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TUBB4B

GENERAL INFORMATION

Gene name

 TUBB4B

Gene description

 Tubulin, beta 4B class IVb

Protein class

 FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

 Supported based on 3 antibodies.
HPA043640 , HPA046280 , CAB010880
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TUBB4B (HGNC Symbol)

Synonyms

 Beta2, TUBB2C

Description

 Tubulin, beta 4B class IVb (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137241213 - 137243707

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188229 (version 83.38)

Entrez gene

 10383

UniProt

 P68371 (UniProt - Evidence at protein level)

neXtProt

 NX_P68371

Antibodypedia

 TUBB4B antibodies

PROTEIN BROWSER
TUBB4B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB4B-001
ENSP00000341289
ENST00000340384
P68371 [Direct mapping]
Tubulin beta-4B chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003725 [double-stranded RNA binding]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0006928 [movement of cell or subcellular component]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0042267 [natural killer cell mediated cytotoxicity]
GO:0042288 [MHC class I protein binding]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
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 445 aa
49.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.