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A majority of cancer tissues displayed moderate to strong cytoplasmic immunoreactivity. Lymphomas and gliomas as well as several cases of testicular and skin cancers were weakly stained or negative.
GENE INFORMATION
Gene name
CERKL (HGNC Symbol)
Synonyms
RP26
Description
Ceramide kinase-like (HGNC Symbol)
Entrez gene summary
This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010]
Q49MI3 [Direct mapping] Ceramide kinase-like protein
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SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014)
Q49MI3 [Direct mapping] Ceramide kinase-like protein
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014)
