Cell atlas - SLC24A5 - The Human Protein Atlas

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SLC24A5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC24A5
Gene description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC24A5 (HGNC Symbol)
Synonyms	JSX, OCA6
Description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	48120972 - 48142672
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188467 (version 83.38)
Entrez gene	283652
UniProt	Q71RS6 (UniProt - Evidence at protein level)
neXtProt	NX_Q71RS6
Antibodypedia	SLC24A5 antibodies

PROTEIN BROWSER

SLC24A5-001	SLC24A5-002	SLC24A5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC24A5-001 ENSP00000341550 ENST00000341459	Q71RS6 [Direct mapping] Sodium/potassium/calcium exchanger 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005802 [trans-Golgi network] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0032588 [trans-Golgi network membrane] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042470 [melanosome] GO:0048022 [negative regulation of melanin biosynthetic process] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	500 aa 54.9 kDa	Yes	>9
SLC24A5-002 ENSP00000453395 ENST00000482911	H0YLZ0 [Direct mapping] Sodium/potassium/calcium exchanger 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005802 [trans-Golgi network] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0048021 [regulation of melanin biosynthetic process] Show all	122 aa 13.9 kDa	Yes	1
SLC24A5-004 ENSP00000389966 ENST00000449382	Q71RS6 [Direct mapping] Sodium/potassium/calcium exchanger 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005802 [trans-Golgi network] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0032588 [trans-Golgi network membrane] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042470 [melanosome] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	440 aa 48 kDa	Yes	9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.