Cell atlas - SERPINA5 - The Human Protein Atlas

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SERPINA5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	SERPINA5
Gene description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Protein class	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056919
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)

1 HPA056919: CACO-2	2 HPA056919: CACO-2	3 HPA056919: U-2 OS
	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
1 2	HPA056919	CACO-2	Mitochondria
3	HPA056919	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	SERPINA5 (HGNC Symbol)
Synonyms	PAI3, PCI, PLANH3, PROCI
Description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	94561442 - 94593120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188488 (version 83.38)
Entrez gene	5104
UniProt	P05154 (UniProt - Evidence at protein level)
neXtProt	NX_P05154
Antibodypedia	SERPINA5 antibodies

PROTEIN BROWSER

SERPINA5-001	SERPINA5-002	SERPINA5-003	SERPINA5-008	SERPINA5-010	SERPINA5-011	SERPINA5-012	SERPINA5-013	SERPINA5-014	SERPINA5-015	SERPINA5-016	SERPINA5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINA5-001 ENSP00000450484 ENST00000554220	G3V264 [Direct mapping] Plasma serine protease inhibitor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	172 aa 19 kDa	Yes	0
SERPINA5-002 ENSP00000450837 ENST00000553780	P05154 [Direct mapping] Plasma serine protease inhibitor A0A024R6N9 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 5, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001972 [retinoic acid binding] GO:0002020 [protease binding] GO:0002080 [acrosomal membrane] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0007283 [spermatogenesis] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0009897 [external side of plasma membrane] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0031091 [platelet alpha granule] GO:0031094 [platelet dense tubular network] GO:0031210 [phosphatidylcholine binding] GO:0032190 [acrosin binding] GO:0036024 [protein C inhibitor-TMPRSS7 complex] GO:0036025 [protein C inhibitor-TMPRSS11E complex] GO:0036026 [protein C inhibitor-PLAT complex] GO:0036027 [protein C inhibitor-PLAU complex] GO:0036028 [protein C inhibitor-thrombin complex] GO:0036029 [protein C inhibitor-KLK3 complex] GO:0036030 [protein C inhibitor-plasma kallikrein complex] GO:0043234 [protein complex] GO:0051346 [negative regulation of hydrolase activity] GO:0070062 [extracellular exosome] GO:0097181 [protein C inhibitor-coagulation factor V complex] GO:0097182 [protein C inhibitor-coagulation factor Xa complex] GO:0097183 [protein C inhibitor-coagulation factor XI complex] Show all	406 aa 45.7 kDa	Yes	0
SERPINA5-003 ENSP00000451126 ENST00000554866	P05154 [Direct mapping] Plasma serine protease inhibitor A0A024R6N9 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 5, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001972 [retinoic acid binding] GO:0002020 [protease binding] GO:0002080 [acrosomal membrane] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0007283 [spermatogenesis] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0009897 [external side of plasma membrane] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0031091 [platelet alpha granule] GO:0031094 [platelet dense tubular network] GO:0031210 [phosphatidylcholine binding] GO:0032190 [acrosin binding] GO:0036024 [protein C inhibitor-TMPRSS7 complex] GO:0036025 [protein C inhibitor-TMPRSS11E complex] GO:0036026 [protein C inhibitor-PLAT complex] GO:0036027 [protein C inhibitor-PLAU complex] GO:0036028 [protein C inhibitor-thrombin complex] GO:0036029 [protein C inhibitor-KLK3 complex] GO:0036030 [protein C inhibitor-plasma kallikrein complex] GO:0043234 [protein complex] GO:0051346 [negative regulation of hydrolase activity] GO:0070062 [extracellular exosome] GO:0097181 [protein C inhibitor-coagulation factor V complex] GO:0097182 [protein C inhibitor-coagulation factor Xa complex] GO:0097183 [protein C inhibitor-coagulation factor XI complex] Show all	406 aa 45.7 kDa	Yes	0
SERPINA5-008 ENSP00000451610 ENST00000554276	P05154 [Direct mapping] Plasma serine protease inhibitor A0A024R6N9 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 5, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001972 [retinoic acid binding] GO:0002020 [protease binding] GO:0002080 [acrosomal membrane] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0007283 [spermatogenesis] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0009897 [external side of plasma membrane] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0031091 [platelet alpha granule] GO:0031094 [platelet dense tubular network] GO:0031210 [phosphatidylcholine binding] GO:0032190 [acrosin binding] GO:0036024 [protein C inhibitor-TMPRSS7 complex] GO:0036025 [protein C inhibitor-TMPRSS11E complex] GO:0036026 [protein C inhibitor-PLAT complex] GO:0036027 [protein C inhibitor-PLAU complex] GO:0036028 [protein C inhibitor-thrombin complex] GO:0036029 [protein C inhibitor-KLK3 complex] GO:0036030 [protein C inhibitor-plasma kallikrein complex] GO:0043234 [protein complex] GO:0051346 [negative regulation of hydrolase activity] GO:0070062 [extracellular exosome] GO:0097181 [protein C inhibitor-coagulation factor V complex] GO:0097182 [protein C inhibitor-coagulation factor Xa complex] GO:0097183 [protein C inhibitor-coagulation factor XI complex] Show all	406 aa 45.7 kDa	Yes	0
SERPINA5-010 ENSP00000451650 ENST00000555681	G3V482 [Direct mapping] Plasma serine protease inhibitor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	144 aa 15.9 kDa	Yes	0
SERPINA5-011 ENSP00000451697 ENST00000554633	G3V4B4 [Direct mapping] Plasma serine protease inhibitor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	86 aa 9.4 kDa	Yes	0
SERPINA5-012 ENSP00000452469 ENST00000554760	G3V5Q9 [Direct mapping] Plasma serine protease inhibitor Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	301 aa 34.1 kDa	Yes	0
SERPINA5-013 ENSP00000451215 ENST00000553511	G3V3F5 [Direct mapping] Plasma serine protease inhibitor Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	90 aa 9.8 kDa	Yes	0
SERPINA5-014 ENSP00000450745 ENST00000556775	G3V2M1 [Direct mapping] Plasma serine protease inhibitor Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	231 aa 25.8 kDa	Yes	0
SERPINA5-015 ENSP00000451487 ENST00000556064	G3V3Y3 [Direct mapping] Plasma serine protease inhibitor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010951 [negative regulation of endopeptidase activity] Show all	24 aa 2.7 kDa	Yes	0
SERPINA5-016 ENSP00000450485 ENST00000557598	G3V265 [Direct mapping] Plasma serine protease inhibitor Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	157 aa 17.3 kDa	Yes	0
SERPINA5-201 ENSP00000333203 ENST00000329597	P05154 [Direct mapping] Plasma serine protease inhibitor A0A024R6N9 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 5, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001972 [retinoic acid binding] GO:0002020 [protease binding] GO:0002080 [acrosomal membrane] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0007283 [spermatogenesis] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0009897 [external side of plasma membrane] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0031091 [platelet alpha granule] GO:0031094 [platelet dense tubular network] GO:0031210 [phosphatidylcholine binding] GO:0032190 [acrosin binding] GO:0036024 [protein C inhibitor-TMPRSS7 complex] GO:0036025 [protein C inhibitor-TMPRSS11E complex] GO:0036026 [protein C inhibitor-PLAT complex] GO:0036027 [protein C inhibitor-PLAU complex] GO:0036028 [protein C inhibitor-thrombin complex] GO:0036029 [protein C inhibitor-KLK3 complex] GO:0036030 [protein C inhibitor-plasma kallikrein complex] GO:0043234 [protein complex] GO:0045861 [negative regulation of proteolysis] GO:0051346 [negative regulation of hydrolase activity] GO:0070062 [extracellular exosome] GO:0097181 [protein C inhibitor-coagulation factor V complex] GO:0097182 [protein C inhibitor-coagulation factor Xa complex] GO:0097183 [protein C inhibitor-coagulation factor XI complex] Show all	406 aa 45.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.