Cell atlas - NKAIN2 - The Human Protein Atlas

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NKAIN2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	NKAIN2
Gene description	Na+/K+ transporting ATPase interacting 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (Karpas-707, HEL, HEK 293)
Protein evidence	Evidence at transcript level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA045860
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, HEL, HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)

1 HPA045860: HEK 293	2 HPA045860: U-2 OS	3 HPA045860: U-251 MG
	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
1	HPA045860	HEK 293	Cytosol
2	HPA045860	U-2 OS	No staining
3	HPA045860	U-251 MG	No staining

GENE INFORMATION
Gene name	NKAIN2 (HGNC Symbol)
Synonyms	FAM77B, TCBA1
Description	Na+/K+ transporting ATPase interacting 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Chromosome	6
Cytoband	q22.31
Chromosome location (bp)	123804141 - 124825657
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000188580 (version 83.38)
Entrez gene	154215
UniProt	Q5VXU1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VXU1
Antibodypedia	NKAIN2 antibodies

PROTEIN BROWSER

NKAIN2-001	NKAIN2-002	NKAIN2-201	NKAIN2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NKAIN2-001 ENSP00000357401 ENST00000368416	Q5VXU1 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0002028 [regulation of sodium ion transport] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	188 aa 21.2 kDa	No	3
NKAIN2-002 ENSP00000357402 ENST00000368417	Q5VXU1 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0002028 [regulation of sodium ion transport] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	208 aa 23.8 kDa	No	3
NKAIN2-201 ENSP00000437798 ENST00000545433	Q5VXU1 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0002028 [regulation of sodium ion transport] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	207 aa 23.8 kDa	No	3
NKAIN2-202 ENSP00000440287 ENST00000546092	F5GY48 [Direct mapping] Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	49 aa 5.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.