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ADRB3

GENERAL INFORMATION

Gene name

 ADRB3

Gene description

 Adrenoceptor beta 3

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (ovary, placenta)
GTEx:Tissue enhanced (ovary, fallopian tube)
FANTOM5:Tissue enhanced (gallbladder, ovary)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, fallopian tube)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, ovary)

GENE INFORMATION

Gene name

 ADRB3

Synonyms

Description

 Adrenoceptor beta 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 37962991 - 37966965

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188778 (version 83.38)

Entrez gene

 155

UniProt

 P13945 (UniProt - Evidence at protein level)

neXtProt

 NX_P13945

Antibodypedia

 ADRB3 antibodies

PROTEIN BROWSER
ADRB3-001
ADRB3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRB3-001
ENSP00000343782
ENST00000345060
P13945 [Direct mapping]
Beta-3 adrenergic receptor
A8KAG8 [Target identity:100%; Query identity:100%]
Adrenergic, beta-3-, receptor, isoform CRA_b; cDNA FLJ78531, highly similar to Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA; cDNA, FLJ94487, Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001659 [temperature homeostasis]
GO:0002024 [diet induced thermogenesis]
GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004939 [beta-adrenergic receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0009409 [response to cold]
GO:0015052 [beta3-adrenergic receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031649 [heat generation]
GO:0031699 [beta-3 adrenergic receptor binding]
GO:0040015 [negative regulation of multicellular organism growth]
GO:0042755 [eating behavior]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0046677 [response to antibiotic]
GO:0050873 [brown fat cell differentiation]
GO:0051379 [epinephrine binding]
GO:0051380 [norepinephrine binding]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 408 aa
43.5 kDa 		No 7
ADRB3-201
ENSP00000480325
ENST00000614635
P13945 [Direct mapping]
Beta-3 adrenergic receptor
A8KAG8 [Target identity:100%; Query identity:100%]
Adrenergic, beta-3-, receptor, isoform CRA_b; cDNA FLJ78531, highly similar to Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA; cDNA, FLJ94487, Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001659 [temperature homeostasis]
GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004939 [beta-adrenergic receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0015052 [beta3-adrenergic receptor activity]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0051379 [epinephrine binding]
GO:0051380 [norepinephrine binding]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 408 aa
43.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.