Expression of MTF1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Metal-regulatory transcription factor 1

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA028604	HPA028689

GENE INFORMATION
Gene name	MTF1
Synonyms
Description	Metal-regulatory transcription factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	37809567 - 37859620
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188786 (version 83.38)
Entrez gene	4520
UniProt	Q14872 (UniProt - Evidence at protein level)
neXtProt	NX_Q14872
Antibodypedia	MTF1 antibodies

PROTEIN BROWSER

MTF1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTF1-001 ENSP00000362127 ENST00000373036	Q14872 [Direct mapping] Metal regulatory transcription factor 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006979 [response to oxidative stress] GO:0010038 [response to metal ion] GO:0035035 [histone acetyltransferase binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046686 [response to cadmium ion] GO:0046872 [metal ion binding] Show all	753 aa 81 kDa	No	0