We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000904 [cell morphogenesis involved in differentiation] GO:0001764 [neuron migration] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0007612 [learning] GO:0007616 [long-term memory] GO:0008236 [serine-type peptidase activity] GO:0008306 [associative learning] GO:0010001 [glial cell differentiation] GO:0010468 [regulation of gene expression] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016358 [dendrite development] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021511 [spinal cord patterning] GO:0021517 [ventral spinal cord development] GO:0021766 [hippocampus development] GO:0021800 [cerebral cortex tangential migration] GO:0021819 [layer formation in cerebral cortex] GO:0021987 [cerebral cortex development] GO:0030425 [dendrite] GO:0030900 [forebrain development] GO:0032008 [positive regulation of TOR signaling] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0035418 [protein localization to synapse] GO:0038026 [reelin-mediated signaling pathway] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048265 [response to pain] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050795 [regulation of behavior] GO:0050804 [modulation of synaptic transmission] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0061003 [positive regulation of dendritic spine morphogenesis] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070325 [lipoprotein particle receptor binding] GO:0070326 [very-low-density lipoprotein particle receptor binding] GO:0090129 [positive regulation of synapse maturation] GO:0097114 [NMDA glutamate receptor clustering] GO:0097119 [postsynaptic density protein 95 clustering] GO:0097120 [receptor localization to synapse] GO:0097477 [lateral motor column neuron migration] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1902078 [positive regulation of lateral motor column neuron migration] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000969 [positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000904 [cell morphogenesis involved in differentiation] GO:0001764 [neuron migration] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0008236 [serine-type peptidase activity] GO:0010001 [glial cell differentiation] GO:0010976 [positive regulation of neuron projection development] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021511 [spinal cord patterning] GO:0021766 [hippocampus development] GO:0021800 [cerebral cortex tangential migration] GO:0030425 [dendrite] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0038026 [reelin-mediated signaling pathway] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048265 [response to pain] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050795 [regulation of behavior] GO:0050804 [modulation of synaptic transmission] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0061003 [positive regulation of dendritic spine morphogenesis] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070325 [lipoprotein particle receptor binding] GO:0070326 [very-low-density lipoprotein particle receptor binding] GO:0090129 [positive regulation of synapse maturation] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000969 [positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]