Expression of LITAF in cancer - Summary

CANCER ATLAS

Gene description

Lipopolysaccharide-induced TNF factor

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006960

GENE INFORMATION
Gene name	LITAF (HGNC Symbol)
Synonyms	FLJ38636, PIG7, SIMPLE, TP53I7
Description	Lipopolysaccharide-induced TNF factor (HGNC Symbol)
Entrez gene summary	Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Chromosome	16
Cytoband	p13.13
Chromosome location (bp)	11547722 - 11636381
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189067 (version 83.38)
Entrez gene	9516
UniProt	Q99732 (UniProt - Evidence at protein level)
neXtProt	NX_Q99732
Antibodypedia	LITAF antibodies

PROTEIN BROWSER

LITAF-001	LITAF-002	LITAF-004	LITAF-005	LITAF-006	LITAF-007	LITAF-008	LITAF-009	LITAF-010	LITAF-011	LITAF-012	LITAF-013	LITAF-016	LITAF-017	LITAF-018	LITAF-019	LITAF-201	LITAF-202	LITAF-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LITAF-001 ENSP00000459533 ENST00000571688	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0001817 [regulation of cytokine production] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007568 [aging] GO:0032496 [response to lipopolysaccharide] GO:0042347 [negative regulation of NF-kappaB import into nucleus] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] GO:0071222 [cellular response to lipopolysaccharide] Show all	161 aa 17.1 kDa	No	1
LITAF-002 ENSP00000397958 ENST00000413364	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	152 aa 15.8 kDa	No	0
LITAF-004 ENSP00000459913 ENST00000574703	I3L2T6 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted intracellular proteins Show all		105 aa 10.7 kDa	No	0
LITAF-005 ENSP00000340118 ENST00000339430	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	161 aa 17.1 kDa	No	1
LITAF-006 ENSP00000459138 ENST00000570904	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	161 aa 17.1 kDa	No	1
LITAF-007 ENSP00000458981 ENST00000574701	I3L1P1 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0043231 [intracellular membrane-bounded organelle] Show all	136 aa 14.2 kDa	No	0
LITAF-008 ENSP00000460133 ENST00000571976	I3L329 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0043231 [intracellular membrane-bounded organelle] Show all	126 aa 13.2 kDa	No	0
LITAF-009 ENSP00000458871 ENST00000570798	I3L1I9 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	137 aa 14.4 kDa	No	1
LITAF-010 ENSP00000461813 ENST00000574763	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	161 aa 17.1 kDa	No	1
LITAF-011 ENSP00000458836 ENST00000572255	I3L1H3 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	68 aa 7.4 kDa	No	1
LITAF-012 ENSP00000460743 ENST00000571627	I3L3U8 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0043231 [intracellular membrane-bounded organelle] Show all	154 aa 16.3 kDa	No	1
LITAF-013 ENSP00000459026 ENST00000571277	I3L1R0 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted intracellular proteins Show all		39 aa 3.9 kDa	No	0
LITAF-016 ENSP00000459603 ENST00000571459	I3L2E2 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted intracellular proteins Show all		75 aa 7.6 kDa	No	0
LITAF-017 ENSP00000461667 ENST00000576036	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	161 aa 17.1 kDa	No	1
LITAF-018 ENSP00000458538 ENST00000576334	I3L133 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted intracellular proteins Show all		33 aa 3.6 kDa	No	0
LITAF-019 ENSP00000459898 ENST00000574848	I3L2T1 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		88 aa 9 kDa	No	0
LITAF-201 ENSP00000371231 ENST00000381810	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	228 aa 23.9 kDa	No	1
LITAF-202 ENSP00000481589 ENST00000620789	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	152 aa 15.8 kDa	No	0
LITAF-203 ENSP00000483114 ENST00000622633	Q99732 [Direct mapping] Lipopolysaccharide-induced tumor necrosis factor-alpha factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0050699 [WW domain binding] Show all	161 aa 17.1 kDa	No	1