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Most cancer cells displayed weak to moderate cytoplasmic positivity. Several carcinoids and lymphomas were strongly stained. Most cervical and renal cancers were negative.
Most cancer cells showed weak to moderate cytoplasmic with additional nuclear membranous staining in several cases. A few hepatocellular carcinomas and melanomas along with occasional urothelial and renal cancers were strongly stained. Several gliomas, lymphomas and prostate cancers were negative.
The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. [provided by RefSeq, Jul 2008]