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Most cancer cells were weak to moderate cytoplasmic stained in several cases. Virtually no staining in lymphomas, ovarian, cervical, lung, skin and testis cancers.
Cancers generally showed moderate staining. Renal and urothelial cancers displayed several strongly positive cases. A majority of gliomas and lymphomas were weakly stained or negative.
Most cancers showed moderate to strong cytoplasmic positivity. Lymphomas and skin cancer were mainly negative.
GENE INFORMATION
Gene name
FHIT (HGNC Symbol)
Synonyms
AP3Aase, FRA3B
Description
Fragile histidine triad (HGNC Symbol)
Entrez gene summary
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006163 [purine nucleotide metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009117 [nucleotide metabolic process] GO:0016787 [hydrolase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0047710 [bis(5'-adenosyl)-triphosphatase activity] GO:0070062 [extracellular exosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006163 [purine nucleotide metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009117 [nucleotide metabolic process] GO:0016787 [hydrolase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0047710 [bis(5'-adenosyl)-triphosphatase activity] GO:0070062 [extracellular exosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
