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Most of the malignant cells displayed weak to moderate cytoplasmic positivity. A few cases of malignant gliomas, malignant lymphomas, colorectal, testicular and pancreatic cancers were strongly stained. A majority of cervical, breast, endometrial, urothelial, stomach and renal cancers were negative.
GENE INFORMATION
Gene name
GSPT2 (HGNC Symbol)
Synonyms
eRF3b, FLJ10441
Description
G1 to S phase transition 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]