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MYBPC1

GENERAL INFORMATION

Gene name

 MYBPC1

Gene description

 Myosin binding protein C, slow type

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021004 , HPA027614
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 MYBPC1

Synonyms

Description

 Myosin binding protein C, slow type (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 12

Cytoband

 q23.2

Chromosome location (bp)

 101568353 - 101686018

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196091 (version 83.38)

Entrez gene

 4604

UniProt

 Q00872 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00872

Antibodypedia

 MYBPC1 antibodies

PROTEIN BROWSER
«
MYBPC1-001
MYBPC1-002
MYBPC1-003
MYBPC1-004
MYBPC1-006
MYBPC1-007
MYBPC1-008
MYBPC1-009
MYBPC1-010
MYBPC1-011
MYBPC1-012
MYBPC1-013
MYBPC1-015
MYBPC1-024
MYBPC1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYBPC1-001
ENSP00000400908
ENST00000452455
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1173 aa
131.7 kDa 		No 0
MYBPC1-002
ENSP00000447362
ENST00000547509
F8VZE0 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1132 aa
127.6 kDa 		No 0
MYBPC1-003
ENSP00000376665
ENST00000392934
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1139 aa
128.4 kDa 		No 0
MYBPC1-004
ENSP00000448175
ENST00000547405
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1120 aa
126.4 kDa 		No 0
MYBPC1-006
ENSP00000354845
ENST00000361685
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1148 aa
129.1 kDa 		No 0
MYBPC1-007
ENSP00000447900
ENST00000553190
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1123 aa
126.5 kDa 		No 0
MYBPC1-008
ENSP00000440034
ENST00000545503
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1146 aa
129.1 kDa 		No 0
MYBPC1-009
ENSP00000354849
ENST00000361466
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1171 aa
131.7 kDa 		No 0
MYBPC1-010
ENSP00000446128
ENST00000536007
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1127 aa
127.1 kDa 		No 0
MYBPC1-011
ENSP00000442847
ENST00000541119
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1134 aa
127.8 kDa 		No 0
MYBPC1-012
ENSP00000447116
ENST00000551300
G3V1V7 [Direct mapping]
Myosin binding protein C, slow type, isoform CRA_e; Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1024 aa
115.5 kDa 		No 0
MYBPC1-013
ENSP00000447660
ENST00000549145
F8VZY0 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1154 aa
129.6 kDa 		No 0
MYBPC1-015
ENSP00000447404
ENST00000550514
F8W1Z9 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 104 aa
12 kDa 		No 0
MYBPC1-024
ENSP00000449702
ENST00000550270
Q00872 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030049 [muscle filament sliding]
GO:0031432 [titin binding]
GO:0032982 [myosin filament]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1141 aa
128.3 kDa 		No 0
MYBPC1-201
ENSP00000388989
ENST00000441232
G3XAI7 [Direct mapping]
Myosin-binding protein C, slow-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 782 aa
88.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.