Expression of SERPINA3 in cancer - Summary

CANCER ATLAS

Gene description

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000893	HPA002560	CAB016647

Tissue	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Tissue	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most breast cancers showed moderate cytoplasmic positivity with a granular pattern. Remaining cancers were generally negative.

GENE INFORMATION
Gene name	SERPINA3 (HGNC Symbol)
Synonyms	AACT, ACT, alpha-1-antichymotrypsin
Description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	94612384 - 94624055
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196136 (version 83.38)
Entrez gene
UniProt	P01011 (UniProt - Evidence at protein level)
neXtProt	NX_P01011
Antibodypedia	SERPINA3 antibodies

PROTEIN BROWSER

SERPINA3-002	SERPINA3-003	SERPINA3-006	SERPINA3-007	SERPINA3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINA3-002 ENSP00000450540 ENST00000467132	P01011 [Direct mapping] Alpha-1-antichymotrypsin Alpha-1-antichymotrypsin His-Pro-less A0A024R6P0 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006953 [acute-phase response] GO:0006954 [inflammatory response] GO:0010951 [negative regulation of endopeptidase activity] GO:0019216 [regulation of lipid metabolic process] GO:0030277 [maintenance of gastrointestinal epithelium] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	423 aa 47.7 kDa	Yes	0
SERPINA3-003 ENSP00000451119 ENST00000482740	G3V3A0 [Direct mapping] Alpha-1-antichymotrypsin; Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	205 aa 23.4 kDa	No	0
SERPINA3-006 ENSP00000452246 ENST00000555820	G3V595 [Direct mapping] Alpha-1-antichymotrypsin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	305 aa 34.6 kDa	Yes	0
SERPINA3-007 ENSP00000376795 ENST00000393080	P01011 [Direct mapping] Alpha-1-antichymotrypsin Alpha-1-antichymotrypsin His-Pro-less A0A024R6P0 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3, isoform CRA_c Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006953 [acute-phase response] GO:0006954 [inflammatory response] GO:0010951 [negative regulation of endopeptidase activity] GO:0019216 [regulation of lipid metabolic process] GO:0030277 [maintenance of gastrointestinal epithelium] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	423 aa 47.7 kDa	Yes	0
SERPINA3-010 ENSP00000481617 ENST00000621603	A0A087WY93 [Direct mapping] Alpha-1-antichymotrypsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	46 aa 5.3 kDa	No	0