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Weak to moderate cytoplasmic immunoreactivity was observed in malignant gliomas, melanomas and skin cancers. Remaining tumors were in general negative.
GENE INFORMATION
Gene name
NLGN3 (HGNC Symbol)
Synonyms
ASPGX1, AUTSX1, HNL3, KIAA1480
Description
Neuroligin 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]