Expression of EPHB4 in cancer - Summary

CANCER ATLAS

Gene description

EPH receptor B4

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB013537

GENE INFORMATION
Gene name	EPHB4 (HGNC Symbol)
Synonyms	HTK, Tyro11
Description	EPH receptor B4 (HGNC Symbol)
Entrez gene summary	Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100802565 - 100827521
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196411 (version 83.38)
Entrez gene	2050
UniProt	P54760 (UniProt - Evidence at protein level)
neXtProt	NX_P54760
Antibodypedia	EPHB4 antibodies

PROTEIN BROWSER

EPHB4-001	EPHB4-005	EPHB4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHB4-001 ENSP00000350896 ENST00000358173	P54760 [Direct mapping] Ephrin type-B receptor 4 Q541P7 [Target identity:100%; Query identity:100%] Receptor protein-tyrosine kinase Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003007 [heart morphogenesis] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] GO:2000525 [positive regulation of T cell costimulation] Show all	987 aa 108.3 kDa	Yes	1
EPHB4-005 ENSP00000353833 ENST00000360620	Q96L35 [Direct mapping] Receptor protein-tyrosine kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	935 aa 102.6 kDa	Yes	1
EPHB4-201 ENSP00000482702 ENST00000616502	P54760 [Direct mapping] Ephrin type-B receptor 4 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0003007 [heart morphogenesis] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	306 aa 33.3 kDa	Yes	0