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Most cancer tissues showed weak to moderate nuclear and cytoplasmic staining. A single case each of melanoma and hepatocellular carcinoma displayed strong nuclear positivity while lymphomas showed cytoplasmic immunoreactivity.
Moderate to strong cytoplasmic positivity was observed in few cases of melanomas, colorectal, breast, testicular, urothelial and pancreatic cancers. Rare case of colorectal, prostate, cervical, endometrial, skin and stomach cancers were moderately positive. Remaining cancer tissues were weakly stained or negative.
Several cases of renal cancers displayed strong nuclear, cytoplasmic and membranous positivity. Moderate nuclear and cytoplasmic staining was observed in many cases of melanomas, squamous cell carcinomas, colorectal, lung, ovarian, urothelial and pancreatic cancers. Remaining cancer tissues were mainly negative.
Most liver cancers, lobular carcinomas of breast and adenocarcinomas of lung along with few stomach cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
NBPF4 (HGNC Symbol)
Synonyms
FLJ32833
Description
Neuroblastoma breakpoint family, member 4 (HGNC Symbol)
Entrez gene summary
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Mar 2013]
