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TRAPPC2

GENERAL INFORMATION

Gene name

 TRAPPC2

Gene description

 Trafficking protein particle complex 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues, including lymphocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB004665
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRAPPC2 (HGNC Symbol)

Synonyms

 hYP38334, MIP-2A, SEDL, SEDT, TRAPPC2, TRS20, ZNF547L

Description

 Trafficking protein particle complex 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 13712244 - 13734635

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196459 (version 83.38)

Entrez gene

 6399

UniProt

 P0DI81 (UniProt - Evidence at protein level)

neXtProt

 NX_P0DI81

Antibodypedia

 TRAPPC2 antibodies

PROTEIN BROWSER
TRAPPC2-002
TRAPPC2-005
TRAPPC2-006
TRAPPC2-008
TRAPPC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRAPPC2-002
ENSP00000369953
ENST00000380579
P0DI81 [Direct mapping]
Trafficking protein particle complex subunit 2
Q6IBE5 [Target identity:100%; Query identity:100%]
Trafficking protein particle complex 2, isoform CRA_a; Trafficking protein particle complex 2, isoform CRA_b; ZNF547 protein; Zinc finger protein 547, isoform CRA_a; cDNA, FLJ94336, Homo sapiens spondyloepiphyseal dysplasia, late (SEDL), mRNA
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008134 [transcription factor binding]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044325 [ion channel binding]
GO:0048208 [COPII vesicle coating]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061024 [membrane organization]
Show all
 140 aa
16.4 kDa 		No 0
TRAPPC2-005
ENSP00000392495
ENST00000458511
P0DI81 [Direct mapping]
Trafficking protein particle complex subunit 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008134 [transcription factor binding]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044325 [ion channel binding]
GO:0048208 [COPII vesicle coating]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061024 [membrane organization]
Show all
 174 aa
20.4 kDa 		No 0
TRAPPC2-006
ENSP00000430725
ENST00000519885
F5H785 [Direct mapping]
Trafficking protein particle complex subunit 2
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
Show all
 113 aa
13.4 kDa 		No 0
TRAPPC2-008
ENSP00000428900
ENST00000518847
E5RFG0 [Direct mapping]
Trafficking protein particle complex subunit 2
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
Show all
 74 aa
8.6 kDa 		No 0
TRAPPC2-201
ENSP00000352708
ENST00000359680
P0DI81 [Direct mapping]
Trafficking protein particle complex subunit 2
Q6IBE5 [Target identity:100%; Query identity:100%]
Trafficking protein particle complex 2, isoform CRA_a; Trafficking protein particle complex 2, isoform CRA_b; ZNF547 protein; Zinc finger protein 547, isoform CRA_a; cDNA, FLJ94336, Homo sapiens spondyloepiphyseal dysplasia, late (SEDL), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008134 [transcription factor binding]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044325 [ion channel binding]
GO:0048208 [COPII vesicle coating]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061024 [membrane organization]
Show all
 140 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.