Expression of MYL6B in cancer - Summary

CANCER ATLAS

Gene description

Myosin, light chain 6B, alkali, smooth muscle and non-muscle

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038887	HPA046859	HPA063034

GENE INFORMATION
Gene name	MYL6B (HGNC Symbol)
Synonyms	MLC1SA
Description	Myosin, light chain 6B, alkali, smooth muscle and non-muscle (HGNC Symbol)
Entrez gene summary	Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Chromosome	12
Cytoband	q13.2
Chromosome location (bp)	56152256 - 56159647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196465 (version 83.38)
Entrez gene	140465
UniProt	P14649 (UniProt - Evidence at protein level)
neXtProt	NX_P14649
Antibodypedia	MYL6B antibodies

PROTEIN BROWSER

MYL6B-001	MYL6B-003	MYL6B-004	MYL6B-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL6B-001 ENSP00000446643 ENST00000550443	P14649 [Direct mapping] Myosin light chain 6B A0A024RB31 [Target identity:100%; Query identity:100%] Myosin, light polypeptide 6B, alkali, smooth muscle and non-muscle, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0007519 [skeletal muscle tissue development] GO:0008307 [structural constituent of muscle] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	208 aa 22.8 kDa	No	0
MYL6B-003 ENSP00000450385 ENST00000553066	P14649 [Direct mapping] Myosin light chain 6B A0A024RB31 [Target identity:100%; Query identity:100%] Myosin, light polypeptide 6B, alkali, smooth muscle and non-muscle, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0007519 [skeletal muscle tissue development] GO:0008307 [structural constituent of muscle] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	208 aa 22.8 kDa	No	0
MYL6B-004 ENSP00000448198 ENST00000551834	F8VSA2 [Direct mapping] Myosin light chain 6B Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 2.8 kDa	No	0
MYL6B-011 ENSP00000446965 ENST00000552568	F8W1I5 [Direct mapping] Myosin light chain 6B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	175 aa 19 kDa	No	0