Expression of SLC6A9 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Protein class

Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013977

GENE INFORMATION
Gene name	SLC6A9 (HGNC Symbol)
Synonyms	GLYT1
Description	Solute carrier family 6 (neurotransmitter transporter, glycine), member 9 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.1
Chromosome location (bp)	43991500 - 44031467
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196517 (version 83.38)
Entrez gene	6536
UniProt	P48067 (UniProt - Evidence at transcript level)
neXtProt	NX_P48067
Antibodypedia	SLC6A9 antibodies

PROTEIN BROWSER

SLC6A9-001	SLC6A9-002	SLC6A9-003	SLC6A9-005	SLC6A9-007	SLC6A9-008	SLC6A9-009	SLC6A9-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A9-001 ENSP00000353791 ENST00000360584	P48067 [Direct mapping] Sodium- and chloride-dependent glycine transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0015187 [glycine transmembrane transporter activity] GO:0015375 [glycine:sodium symporter activity] GO:0015816 [glycine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0060092 [regulation of synaptic transmission, glycinergic] GO:0061537 [glycine secretion, neurotransmission] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	706 aa 78.3 kDa	No	>9
SLC6A9-002 ENSP00000350362 ENST00000357730	P48067 [Direct mapping] Sodium- and chloride-dependent glycine transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0015375 [glycine:sodium symporter activity] GO:0015816 [glycine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0060092 [regulation of synaptic transmission, glycinergic] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	652 aa 72.5 kDa	No	>9
SLC6A9-003 ENSP00000361384 ENST00000372310	P48067 [Direct mapping] Sodium- and chloride-dependent glycine transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0015375 [glycine:sodium symporter activity] GO:0015816 [glycine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0060092 [regulation of synaptic transmission, glycinergic] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	633 aa 70.6 kDa	No	>9
SLC6A9-005 ENSP00000434460 ENST00000475075	B7Z589 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] Show all	522 aa 58.4 kDa	No	>9
SLC6A9-007 ENSP00000433241 ENST00000466926	E9PLM5 [Direct mapping] Sodium- and chloride-dependent glycine transporter 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] Show all	116 aa 12.5 kDa	Yes	0
SLC6A9-008 ENSP00000361381 ENST00000372307	B7Z3A9 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] Show all	574 aa 63.9 kDa	No	9
SLC6A9-009 ENSP00000361380 ENST00000372306	J3KPA5 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] Show all	579 aa 63.1 kDa	No	>9
SLC6A9-011 ENSP00000435652 ENST00000528803	E9PJ65 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005283 [sodium:amino acid symporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] Show all	134 aa 14.6 kDa	No	2