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AFAP1

CANCER ATLAS

Gene description

 Actin filament associated protein 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA015642
CAB024712

GENE INFORMATION

Gene name

 AFAP1 (HGNC Symbol)

Synonyms

 AFAP, AFAP-110

Description

 Actin filament associated protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

 4

Cytoband

 p16.1

Chromosome location (bp)

 7758714 - 7939926

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196526 (version 83.38)

Entrez gene

 60312

UniProt

 Q8N556 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N556

Antibodypedia

 AFAP1 antibodies

PROTEIN BROWSER
AFAP1-001
AFAP1-002
AFAP1-008
AFAP1-201
AFAP1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AFAP1-001
ENSP00000353402
ENST00000360265
Q8N556 [Direct mapping]
Actin filament-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0009966 [regulation of signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051493 [regulation of cytoskeleton organization]
Show all
 730 aa
80.7 kDa 		No 0
AFAP1-002
ENSP00000371983
ENST00000382543
Q8N556 [Direct mapping]
Actin filament-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0009966 [regulation of signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051493 [regulation of cytoskeleton organization]
Show all
 814 aa
89.8 kDa 		No 0
AFAP1-008
ENSP00000483962
ENST00000614385
A0A087X177 [Direct mapping]
Actin filament-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009966 [regulation of signal transduction]
GO:0051493 [regulation of cytoskeleton organization]
Show all
 92 aa
9.7 kDa 		No 0
AFAP1-201
ENSP00000351245
ENST00000358461
Q8N556 [Direct mapping]
Actin filament-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0009966 [regulation of signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051493 [regulation of cytoskeleton organization]
Show all
 730 aa
80.7 kDa 		No 0
AFAP1-202
ENSP00000410689
ENST00000420658
Q8N556 [Direct mapping]
Actin filament-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0009966 [regulation of signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051493 [regulation of cytoskeleton organization]
Show all
 814 aa
89.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.