Tissue expression of NACA - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NACA
Gene description	Nascent polypeptide-associated complex alpha subunit
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NACA (HGNC Symbol)
Synonyms	NACA1
Description	Nascent polypeptide-associated complex alpha subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	56712428 - 56731628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196531 (version 83.38)
Entrez gene	4666
UniProt	E9PAV3 (UniProt - Evidence at protein level), Q13765 (UniProt - Evidence at protein level)
neXtProt	NX_E9PAV3, NX_Q13765
Antibodypedia	NACA antibodies

PROTEIN BROWSER

NACA-001	NACA-002	NACA-003	NACA-004	NACA-005	NACA-006	NACA-007	NACA-011	NACA-012	NACA-014	NACA-018	NACA-020	NACA-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NACA-001 ENSP00000349212 ENST00000356769	Q13765 [Direct mapping] Nascent polypeptide-associated complex subunit alpha A0A024RB41 [Target identity:100%; Query identity:100%] HCG2016482, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003231 [cardiac ventricle development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005854 [nascent polypeptide-associated complex] GO:0006351 [transcription, DNA-templated] GO:0006412 [translation] GO:0010664 [negative regulation of striated muscle cell apoptotic process] GO:0015031 [protein transport] GO:0016032 [viral process] GO:0043403 [skeletal muscle tissue regeneration] GO:0048633 [positive regulation of skeletal muscle tissue growth] GO:0048742 [regulation of skeletal muscle fiber development] GO:0061384 [heart trabecula morphogenesis] GO:0070062 [extracellular exosome] GO:1901227 [negative regulation of transcription from RNA polymerase II promoter involved in heart development] GO:1901228 [positive regulation of transcription from RNA polymerase II promoter involved in heart development] GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis] Show all	215 aa 23.4 kDa	No	0
NACA-002 ENSP00000447821 ENST00000552540	Q13765 [Direct mapping] Nascent polypeptide-associated complex subunit alpha A0A024RB41 [Target identity:100%; Query identity:100%] HCG2016482, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003231 [cardiac ventricle development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005854 [nascent polypeptide-associated complex] GO:0006351 [transcription, DNA-templated] GO:0006412 [translation] GO:0010664 [negative regulation of striated muscle cell apoptotic process] GO:0015031 [protein transport] GO:0016032 [viral process] GO:0043403 [skeletal muscle tissue regeneration] GO:0048633 [positive regulation of skeletal muscle tissue growth] GO:0048742 [regulation of skeletal muscle fiber development] GO:0061384 [heart trabecula morphogenesis] GO:0070062 [extracellular exosome] GO:1901227 [negative regulation of transcription from RNA polymerase II promoter involved in heart development] GO:1901228 [positive regulation of transcription from RNA polymerase II promoter involved in heart development] GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis] Show all	215 aa 23.4 kDa	No	0
NACA-003 ENSP00000377469 ENST00000393891	Q13765 [Direct mapping] Nascent polypeptide-associated complex subunit alpha A0A024RB41 [Target identity:100%; Query identity:100%] HCG2016482, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003231 [cardiac ventricle development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005854 [nascent polypeptide-associated complex] GO:0006351 [transcription, DNA-templated] GO:0006412 [translation] GO:0010664 [negative regulation of striated muscle cell apoptotic process] GO:0015031 [protein transport] GO:0016032 [viral process] GO:0043403 [skeletal muscle tissue regeneration] GO:0048633 [positive regulation of skeletal muscle tissue growth] GO:0048742 [regulation of skeletal muscle fiber development] GO:0061384 [heart trabecula morphogenesis] GO:0070062 [extracellular exosome] GO:1901227 [negative regulation of transcription from RNA polymerase II promoter involved in heart development] GO:1901228 [positive regulation of transcription from RNA polymerase II promoter involved in heart development] GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis] Show all	215 aa 23.4 kDa	No	0
NACA-004 ENSP00000448035 ENST00000550952	E9PAV3 [Direct mapping] Nascent polypeptide-associated complex subunit alpha, muscle-specific form Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	925 aa 94.7 kDa	No	0
NACA-005 ENSP00000446801 ENST00000546392	Q13765 [Direct mapping] Nascent polypeptide-associated complex subunit alpha A0A024RB41 [Target identity:100%; Query identity:100%] HCG2016482, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003231 [cardiac ventricle development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005854 [nascent polypeptide-associated complex] GO:0006351 [transcription, DNA-templated] GO:0006412 [translation] GO:0010664 [negative regulation of striated muscle cell apoptotic process] GO:0015031 [protein transport] GO:0016032 [viral process] GO:0043403 [skeletal muscle tissue regeneration] GO:0048633 [positive regulation of skeletal muscle tissue growth] GO:0048742 [regulation of skeletal muscle fiber development] GO:0061384 [heart trabecula morphogenesis] GO:0070062 [extracellular exosome] GO:1901227 [negative regulation of transcription from RNA polymerase II promoter involved in heart development] GO:1901228 [positive regulation of transcription from RNA polymerase II promoter involved in heart development] GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis] Show all	215 aa 23.4 kDa	No	0
NACA-006 ENSP00000447666 ENST00000546917		Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.6 kDa	No	0
NACA-007 ENSP00000447133 ENST00000549259	F8W0W4 [Direct mapping] Nascent polypeptide-associated complex subunit alpha Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.5 kDa	No	0
NACA-011 ENSP00000447705 ENST00000548563	F8VZJ2 [Direct mapping] Nascent polypeptide-associated complex subunit alpha Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15 kDa	No	0
NACA-012 ENSP00000446933 ENST00000546862	F8W1N5 [Direct mapping] Nascent polypeptide-associated complex subunit alpha Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.8 kDa	No	0
NACA-014 ENSP00000450383 ENST00000552055	F8VNW4 [Direct mapping] Nascent polypeptide-associated complex subunit alpha Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.1 kDa	No	0
NACA-018 ENSP00000448039 ENST00000550920	H0YHX9 [Direct mapping] Nascent polypeptide-associated complex subunit alpha Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		213 aa 22.9 kDa	No	0
NACA-020 ENSP00000447764 ENST00000549855	F8VZ58 [Direct mapping] Nascent polypeptide-associated complex subunit alpha Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		126 aa 13.6 kDa	No	0
NACA-201 ENSP00000403817 ENST00000454682	E9PAV3 [Direct mapping] Nascent polypeptide-associated complex subunit alpha, muscle-specific form Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	2078 aa 205.4 kDa	No	0