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WNK lysine deficient protein kinase 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0005923 [bicellular tight junction] GO:0006468 [protein phosphorylation] GO:0010765 [positive regulation of sodium ion transport] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0019869 [chloride channel inhibitor activity] GO:0032414 [positive regulation of ion transmembrane transporter activity] GO:0035556 [intracellular signal transduction] GO:0043066 [negative regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0051928 [positive regulation of calcium ion transport] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:2000021 [regulation of ion homeostasis] GO:2000651 [positive regulation of sodium ion transmembrane transporter activity] GO:2000682 [positive regulation of rubidium ion transport] GO:2000688 [positive regulation of rubidium ion transmembrane transporter activity]
Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0005923 [bicellular tight junction] GO:0006468 [protein phosphorylation] GO:0010765 [positive regulation of sodium ion transport] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0019869 [chloride channel inhibitor activity] GO:0032414 [positive regulation of ion transmembrane transporter activity] GO:0035556 [intracellular signal transduction] GO:0043066 [negative regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0051928 [positive regulation of calcium ion transport] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090188 [negative regulation of pancreatic juice secretion] GO:2000021 [regulation of ion homeostasis] GO:2000651 [positive regulation of sodium ion transmembrane transporter activity] GO:2000682 [positive regulation of rubidium ion transport] GO:2000688 [positive regulation of rubidium ion transmembrane transporter activity]