Expression of VKORC1L1 in cancer - Summary

CANCER ATLAS

Gene description

Vitamin K epoxide reductase complex, subunit 1-like 1

Protein class

Enzymes, FDA approved drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053954

GENE INFORMATION
Gene name	VKORC1L1
Synonyms
Description	Vitamin K epoxide reductase complex, subunit 1-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q11.21
Chromosome location (bp)	65873267 - 65959563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196715 (version 83.38)
Entrez gene	154807
UniProt	Q8N0U8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N0U8
Antibodypedia	VKORC1L1 antibodies

PROTEIN BROWSER

VKORC1L1-001	VKORC1L1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VKORC1L1-001 ENSP00000353998 ENST00000360768	Q8N0U8 [Direct mapping] Vitamin K epoxide reductase complex subunit 1-like protein 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0034599 [cellular response to oxidative stress] GO:0042373 [vitamin K metabolic process] GO:0047057 [vitamin-K-epoxide reductase (warfarin-sensitive) activity] GO:0048038 [quinone binding] GO:0055114 [oxidation-reduction process] Show all	176 aa 19.8 kDa	No	4
VKORC1L1-002 ENSP00000403077 ENST00000434382	Q8N0U8 [Direct mapping] Vitamin K epoxide reductase complex subunit 1-like protein 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0034599 [cellular response to oxidative stress] GO:0042373 [vitamin K metabolic process] GO:0047057 [vitamin-K-epoxide reductase (warfarin-sensitive) activity] GO:0048038 [quinone binding] GO:0055114 [oxidation-reduction process] Show all	177 aa 19.8 kDa	No	2