Cell atlas - DAPK1 - The Human Protein Atlas

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DAPK1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	DAPK1
Gene description	Death-associated protein kinase 1
Protein class	Cancer-related genes Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. CAB037302
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome.

Main location

Centrosome (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB037302	A-431	Centrosome	Intensity
	CAB037302	U-2 OS	Centrosome	Intensity
	CAB037302	U-251 MG	Centrosome	Intensity

GENE INFORMATION
Gene name	DAPK1 (HGNC Symbol)
Synonyms	DAPK
Description	Death-associated protein kinase 1 (HGNC Symbol)
Entrez gene summary	Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Chromosome	9
Cytoband	q21.33
Chromosome location (bp)	87497228 - 87708633
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196730 (version 83.38)
Entrez gene	1612
UniProt	P53355 (UniProt - Evidence at protein level)
neXtProt	NX_P53355
Antibodypedia	DAPK1 antibodies

PROTEIN BROWSER

DAPK1-001	DAPK1-008	DAPK1-010	DAPK1-011	DAPK1-201	DAPK1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAPK1-001 ENSP00000350785 ENST00000358077	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-008 ENSP00000417076 ENST00000472284	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-010 ENSP00000386135 ENST00000408954	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1
DAPK1-011 ENSP00000419026 ENST00000491893	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1364 aa 152.5 kDa	No	1
DAPK1-201 ENSP00000418885 ENST00000469640	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1364 aa 152.5 kDa	No	1
DAPK1-202 ENSP00000484267 ENST00000622514	P53355 [Direct mapping] Death-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0010506 [regulation of autophagy] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0017075 [syntaxin-1 binding] GO:0017148 [negative regulation of translation] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0046777 [protein autophosphorylation] GO:0071346 [cellular response to interferon-gamma] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] Show all	1430 aa 160 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.