We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Few cases of cholangiocarcinomas and follicular adenoma carcinoma of thyroid showed moderate cytoplasmic staining. A subset of tumor cells in a single case of renal and stomach cancers showed strong positivity. Remaining cancer tissues were negative.
A single case of adenocarcinoma of the lung showed strong cytoplasmic and membranous positivity. Moderate cytoplasmic and membranous immunoreactivity was observed in a few cases of stomach, colorectal and pancreatic cancers. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
COL27A1 (HGNC Symbol)
Synonyms
FLJ11895, KIAA1870, MGC11337
Description
Collagen, type XXVII, alpha 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Sep 2014]