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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ADA
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADA

Gene description

Adenosine deaminase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (duodenum)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Membrane and cytoplasmic expression in duodenum.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 3 antibodies.
HPA001399 , HPA023884 , CAB004307
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ADA

Synonyms

Description

Adenosine deaminase (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

44619522 - 44652233

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196839 (version 83.38)

Entrez gene

100

UniProt

P00813 (UniProt - Evidence at protein level)

neXtProt

NX_P00813

Antibodypedia

ADA antibodies

PROTEIN BROWSER

ADA-001
ADA-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADA-001
ENSP00000361965
ENST00000372874
P00813 [Direct mapping]
Adenosine deaminase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001821 [histamine secretion]
GO:0001829 [trophectodermal cell differentiation]
GO:0001883 [purine nucleoside binding]
GO:0001889 [liver development]
GO:0001890 [placenta development]
GO:0002314 [germinal center B cell differentiation]
GO:0002636 [positive regulation of germinal center formation]
GO:0002686 [negative regulation of leukocyte migration]
GO:0002906 [negative regulation of mature B cell apoptotic process]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006144 [purine nucleobase metabolic process]
GO:0006154 [adenosine catabolic process]
GO:0006157 [deoxyadenosine catabolic process]
GO:0007568 [aging]
GO:0008270 [zinc ion binding]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010460 [positive regulation of heart rate]
GO:0016020 [membrane]
GO:0019239 [deaminase activity]
GO:0030054 [cell junction]
GO:0030324 [lung development]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032261 [purine nucleotide salvage]
GO:0032839 [dendrite cytoplasm]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0033197 [response to vitamin E]
GO:0033632 [regulation of cell-cell adhesion mediated by integrin]
GO:0042110 [T cell activation]
GO:0042323 [negative regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043101 [purine-containing compound salvage]
GO:0043103 [hypoxanthine salvage]
GO:0043278 [response to morphine]
GO:0044281 [small molecule metabolic process]
GO:0045187 [regulation of circadian sleep/wake cycle, sleep]
GO:0045580 [regulation of T cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046061 [dATP catabolic process]
GO:0046101 [hypoxanthine biosynthetic process]
GO:0046103 [inosine biosynthetic process]
GO:0046111 [xanthine biosynthetic process]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0048286 [lung alveolus development]
GO:0048541 [Peyer's patch development]
GO:0048566 [embryonic digestive tract development]
GO:0050728 [negative regulation of inflammatory response]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0060169 [negative regulation of adenosine receptor signaling pathway]
GO:0060205 [cytoplasmic membrane-bounded vesicle lumen]
GO:0060407 [negative regulation of penile erection]
GO:0070244 [negative regulation of thymocyte apoptotic process]
GO:0070256 [negative regulation of mucus secretion]
Show all
363 aa
40.8 kDa
No 0
ADA-008
ENSP00000441818
ENST00000537820
F5GWI4 [Direct mapping]
Adenosine deaminase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0043103 [hypoxanthine salvage]
Show all
339 aa
38.3 kDa
No 0

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