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Cancer cells showed weak to moderate nuclear staining. Gliomas along with occasional cases of breast and urothelial cancers showed strong positivity.
GENE INFORMATION
Gene name
HIST1H2AD (HGNC Symbol)
Synonyms
H2A.3, H2A/g, H2AFG
Description
Histone cluster 1, H2ad (HGNC Symbol)
Entrez gene summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
