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Malignant cells displayed moderate cytoplasmic immunoreactivity. Several cases of endometrial and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
AP2A1 (HGNC Symbol)
Synonyms
ADTAA, CLAPA1
Description
Adaptor-related protein complex 2, alpha 1 subunit (HGNC Symbol)
Entrez gene summary
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]