Expression of SLC25A29 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29

Protein class

Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030781

GENE INFORMATION
Gene name	SLC25A29 (HGNC Symbol)
Synonyms	C14orf69, FLJ38975
Description	Solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	100291111 - 100306547
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197119 (version 83.38)
Entrez gene	123096
UniProt	Q8N8R3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8R3
Antibodypedia	SLC25A29 antibodies

PROTEIN BROWSER

SLC25A29-002	SLC25A29-003	SLC25A29-005	SLC25A29-006	SLC25A29-011	SLC25A29-019	SLC25A29-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A29-002 ENSP00000352167 ENST00000359232	Q8N8R3 [Direct mapping] Mitochondrial basic amino acids transporter Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006844 [acyl carnitine transport] GO:0015227 [acyl carnitine transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:1902616 [acyl carnitine transmembrane transport] Show all	303 aa 32.1 kDa	No	0
SLC25A29-003 ENSP00000376640 ENST00000392908	Q8N8R3 [Direct mapping] Mitochondrial basic amino acids transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	145 aa 14.5 kDa	No	0
SLC25A29-005 ENSP00000450913 ENST00000554912	Q8N8R3 [Direct mapping] Mitochondrial basic amino acids transporter Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	237 aa 25.1 kDa	No	0
SLC25A29-006 ENSP00000452446 ENST00000556505	Q8N8R3 [Direct mapping] Mitochondrial basic amino acids transporter Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	237 aa 25.1 kDa	No	0
SLC25A29-011 ENSP00000451644 ENST00000554060	G3V477 [Direct mapping] Mitochondrial basic amino acids transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 13.8 kDa	No	0
SLC25A29-019 ENSP00000452078 ENST00000555927	Q8N8R3 [Direct mapping] Mitochondrial basic amino acids transporter Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	237 aa 25.1 kDa	No	0
SLC25A29-021 ENSP00000452324 ENST00000554291	G3V5F4 [Direct mapping] Mitochondrial basic amino acids transporter Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	130 aa 13.8 kDa	No	0