Cell atlas - PGAP1 - The Human Protein Atlas

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PGAP1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PGAP1
Gene description	Post-GPI attachment to proteins 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PGAP1 (HGNC Symbol)
Synonyms	Bst1, FLJ12377, SPG67
Description	Post-GPI attachment to proteins 1 (HGNC Symbol)
Entrez gene summary	PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	196833004 - 196927796
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197121 (version 83.38)
Entrez gene	80055
UniProt	Q75T13 (UniProt - Evidence at protein level)
neXtProt	NX_Q75T13
Antibodypedia	PGAP1 antibodies

PROTEIN BROWSER

PGAP1-001	PGAP1-003	PGAP1-005	PGAP1-006	PGAP1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGAP1-001 ENSP00000346809 ENST00000354764	Q75T13 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006505 [GPI anchor metabolic process] GO:0006506 [GPI anchor biosynthetic process] GO:0006886 [intracellular protein transport] GO:0007605 [sensory perception of sound] GO:0009880 [embryonic pattern specification] GO:0009948 [anterior/posterior axis specification] GO:0015798 [myo-inositol transport] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0021871 [forebrain regionalization] GO:0042578 [phosphoric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0060322 [head development] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	922 aa 105.4 kDa	No	7
PGAP1-003 ENSP00000390555 ENST00000422444	H7BZN8 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	159 aa 18 kDa	No	3
PGAP1-005 ENSP00000387028 ENST00000409475	Q75T13 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006505 [GPI anchor metabolic process] GO:0006886 [intracellular protein transport] GO:0015798 [myo-inositol transport] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0042578 [phosphoric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	592 aa 68 kDa	No	1
PGAP1-006 ENSP00000386802 ENST00000409188	B4DYY6 [Direct mapping] GPI inositol-deacylase; cDNA FLJ51154, highly similar to Homo sapiens GPI deacylase (PGAP1), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006505 [GPI anchor metabolic process] GO:0006886 [intracellular protein transport] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	304 aa 34.4 kDa	No	0
PGAP1-011 ENSP00000363870 ENST00000374738	A6NI33 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006505 [GPI anchor metabolic process] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	182 aa 21.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.