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Several cases of cervical, skin, pancreatic, urothelial, head and neck cancers displayed moderate to strong cytoplasmic and membranous positivity. Many cases of colorectal, lung and stomach cancers along with rare ovarian, testis, liver cancers and carcinoid showed moderate positivity. Remaining cancer tissues were weakly stained or negative.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005080 [protein kinase C binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0009615 [response to virus] GO:0010447 [response to acidic pH] GO:0010628 [positive regulation of gene expression] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway] GO:0010907 [positive regulation of glucose metabolic process] GO:0014069 [postsynaptic density] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016337 [single organismal cell-cell adhesion] GO:0016477 [cell migration] GO:0018105 [peptidyl-serine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030331 [estrogen receptor binding] GO:0030900 [forebrain development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031648 [protein destabilization] GO:0031667 [response to nutrient levels] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032148 [activation of protein kinase B activity] GO:0032403 [protein complex binding] GO:0032463 [negative regulation of protein homooligomerization] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0033625 [positive regulation of integrin activation] GO:0034332 [adherens junction organization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0034614 [cellular response to reactive oxygen species] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043393 [regulation of protein binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044325 [ion channel binding] GO:0045056 [transcytosis] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045785 [positive regulation of cell adhesion] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048477 [oogenesis] GO:0050715 [positive regulation of cytokine secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050839 [cell adhesion molecule binding] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051222 [positive regulation of protein transport] GO:0051385 [response to mineralocorticoid] GO:0051427 [hormone receptor binding] GO:0051602 [response to electrical stimulus] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0060065 [uterus development] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0060491 [regulation of cell projection assembly] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070542 [response to fatty acid] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071222 [cellular response to lipopolysaccharide] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071498 [cellular response to fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071801 [regulation of podosome assembly] GO:0071803 [positive regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097110 [scaffold protein binding] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]