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ACSL5

GENERAL INFORMATION

Gene name

 ACSL5

Gene description

 Acyl-CoA synthetase long-chain family member 5

Protein class

 Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in selected tissues, most abundant in the intestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA007162 , CAB062546
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 ACSL5 (HGNC Symbol)

Synonyms

 ACS2, ACS5, FACL5

Description

 Acyl-CoA synthetase long-chain family member 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q25.2

Chromosome location (bp)

 112374018 - 112428380

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197142 (version 83.38)

Entrez gene

 51703

UniProt

 Q9ULC5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULC5

Antibodypedia

 ACSL5 antibodies

PROTEIN BROWSER
ACSL5-001
ACSL5-002
ACSL5-201
ACSL5-202
ACSL5-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACSL5-001
ENSP00000346223
ENST00000354273
Q9ULC5 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 5
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 683 aa
76 kDa 		No 3
ACSL5-002
ENSP00000346680
ENST00000354655
Q9ULC5 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 5
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 683 aa
76 kDa 		No 3
ACSL5-201
ENSP00000348429
ENST00000356116
Q9ULC5 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 5
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 739 aa
82.3 kDa 		No 4
ACSL5-202
ENSP00000376796
ENST00000393081
Q9ULC5 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 5
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 683 aa
76 kDa 		No 3
ACSL5-203
ENSP00000403647
ENST00000433418
Q9ULC5 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 5
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 659 aa
73.3 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.