Expression of ENTPD4 in cancer - Summary

CANCER ATLAS

Gene description

Ectonucleoside triphosphate diphosphohydrolase 4

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017655

GENE INFORMATION
Gene name	ENTPD4 (HGNC Symbol)
Synonyms	KIAA0392, LALP70, LAP70, LYSAL1, NTPDase-4, UDPase
Description	Ectonucleoside triphosphate diphosphohydrolase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	23385783 - 23457695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197217 (version 83.38)
Entrez gene	9583
UniProt	Q9Y227 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y227
Antibodypedia	ENTPD4 antibodies

PROTEIN BROWSER

ENTPD4-001	ENTPD4-002	ENTPD4-004	ENTPD4-005	ENTPD4-006	ENTPD4-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENTPD4-001 ENSP00000351520 ENST00000358689	Q9Y227 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 4 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000421 [autophagosome membrane] GO:0006256 [UDP catabolic process] GO:0016787 [hydrolase activity] GO:0030173 [integral component of Golgi membrane] GO:0031410 [cytoplasmic vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0045134 [uridine-diphosphatase activity] Show all	616 aa 70.3 kDa	No	2
ENTPD4-002 ENSP00000408573 ENST00000417069	Q9Y227 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 4 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000421 [autophagosome membrane] GO:0006256 [UDP catabolic process] GO:0016787 [hydrolase activity] GO:0030173 [integral component of Golgi membrane] GO:0031410 [cytoplasmic vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0045134 [uridine-diphosphatase activity] Show all	608 aa 69.4 kDa	No	2
ENTPD4-004 ENSP00000348536 ENST00000356206	Q8NE73 [Direct mapping] ENTPD4 protein; Ectonucleoside triphosphate diphosphohydrolase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	571 aa 64.9 kDa	No	1
ENTPD4-005 ENSP00000429455 ENST00000518718	E5RIB2 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	127 aa 14.4 kDa	No	0
ENTPD4-006 ENSP00000427724 ENST00000519839	H0YAN2 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 4 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	117 aa 13.5 kDa	No	0
ENTPD4-012 ENSP00000430579 ENST00000518471	H0YBY8 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 4 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	214 aa 24.7 kDa	No	0