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Most hepatocellular carcinomas, gliomas, thyroid, cervical and breast cancers showed moderate to strong staining while cases of carcinoids, melanomas, colorectal, skin, urothelial and pancreatic cancers showed moderate immunoreactivity. Remaining cancer cells were in general weakly stained or negative.
Most cancer cells were moderately stained. Cases of ovarian cancers displayed strong staining. Testicular cancers as well as a majority of lung cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SVIL
Synonyms
Description
Supervillin (HGNC Symbol)
Entrez gene summary
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Jul 2008]
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
