Cell atlas - TRIM33 - The Human Protein Atlas

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TRIM33

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	TRIM33
Gene description	Tripartite motif containing 33
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA004345
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleoplasm.

Main location

Vesicles (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004345	A-431	Nucleoplasm
	HPA004345	A-431	Vesicles
	HPA004345	U-2 OS	Vesicles
	HPA004345	U-251 MG	Nucleoplasm
	HPA004345	U-251 MG	Vesicles

GENE INFORMATION
Gene name	TRIM33 (HGNC Symbol)
Synonyms	FLJ11429, KIAA1113, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
Description	Tripartite motif containing 33 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	114392777 - 114511160
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197323 (version 83.38)
Entrez gene	51592
UniProt	Q9UPN9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPN9
Antibodypedia	TRIM33 antibodies

PROTEIN BROWSER

TRIM33-001	TRIM33-002	TRIM33-003	TRIM33-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM33-001 ENSP00000351250 ENST00000358465	Q9UPN9 [Direct mapping] E3 ubiquitin-protein ligase TRIM33 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0030514 [negative regulation of BMP signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] Show all	1127 aa 122.5 kDa	No	0
TRIM33-002 ENSP00000358556 ENST00000369543	Q9UPN9 [Direct mapping] E3 ubiquitin-protein ligase TRIM33 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0030514 [negative regulation of BMP signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] Show all	1110 aa 120.5 kDa	No	0
TRIM33-003 ENSP00000402333 ENST00000448034	H0Y612 [Direct mapping] E3 ubiquitin-protein ligase TRIM33 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	888 aa 98.9 kDa	No	0
TRIM33-201 ENSP00000412077 ENST00000450349	E7EN20 [Direct mapping] E3 ubiquitin-protein ligase TRIM33 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	1119 aa 121.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.