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SLC22A5

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GENERAL INFORMATION

Gene name

 SLC22A5

Gene description

 Solute carrier family 22 (organic cation/carnitine transporter), member 5

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Cell line enhanced (SiHa)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA063062
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA063062 HeLa Mitochondria
HPA063062 SiHa Mitochondria
HPA063062 U-2 OS Mitochondria

GENE INFORMATION

Gene name

 SLC22A5 (HGNC Symbol)

Synonyms

 CDSP, OCTN2, SCD

Description

 Solute carrier family 22 (organic cation/carnitine transporter), member 5 (HGNC Symbol)

Entrez gene summary

 Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 132369752 - 132395614

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197375 (version 83.38)

Entrez gene

 6584

UniProt

 O76082 (UniProt - Evidence at protein level)

neXtProt

 NX_O76082

Antibodypedia

 SLC22A5 antibodies

PROTEIN BROWSER
SLC22A5-001
SLC22A5-004
SLC22A5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A5-001
ENSP00000245407
ENST00000245407
O76082 [Direct mapping]
Solute carrier family 22 member 5
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0006855 [drug transmembrane transport]
GO:0009437 [carnitine metabolic process]
GO:0015075 [ion transmembrane transporter activity]
GO:0015226 [carnitine transmembrane transporter activity]
GO:0015238 [drug transmembrane transporter activity]
GO:0015293 [symporter activity]
GO:0015491 [cation:cation antiporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015697 [quaternary ammonium group transport]
GO:0015879 [carnitine transport]
GO:0015893 [drug transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0030165 [PDZ domain binding]
GO:0031526 [brush border membrane]
GO:0034220 [ion transmembrane transport]
GO:0052106 [quorum sensing involved in interaction with host]
GO:0055085 [transmembrane transport]
GO:0060731 [positive regulation of intestinal epithelial structure maintenance]
GO:0070062 [extracellular exosome]
GO:0070715 [sodium-dependent organic cation transport]
GO:0072337 [modified amino acid transport]
GO:1902603 [carnitine transmembrane transport]
Show all
 557 aa
62.8 kDa 		No >9
SLC22A5-004
ENSP00000388838
ENST00000415928
H7BZC0 [Direct mapping]
Solute carrier family 22 member 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0055085 [transmembrane transport]
Show all
 240 aa
27 kDa 		No 5
SLC22A5-201
ENSP00000402760
ENST00000435065
O76082 [Direct mapping]
Solute carrier family 22 member 5
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0006855 [drug transmembrane transport]
GO:0009437 [carnitine metabolic process]
GO:0015075 [ion transmembrane transporter activity]
GO:0015226 [carnitine transmembrane transporter activity]
GO:0015238 [drug transmembrane transporter activity]
GO:0015293 [symporter activity]
GO:0015491 [cation:cation antiporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015697 [quaternary ammonium group transport]
GO:0015879 [carnitine transport]
GO:0015893 [drug transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0030165 [PDZ domain binding]
GO:0031526 [brush border membrane]
GO:0034220 [ion transmembrane transport]
GO:0052106 [quorum sensing involved in interaction with host]
GO:0055085 [transmembrane transport]
GO:0060731 [positive regulation of intestinal epithelial structure maintenance]
GO:0070062 [extracellular exosome]
GO:0070715 [sodium-dependent organic cation transport]
GO:0072337 [modified amino acid transport]
GO:1902603 [carnitine transmembrane transport]
Show all
 581 aa
65.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.