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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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C5AR1
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

C5AR1

Gene description

Complement component 5a receptor 1

Protein class

CD markers
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (appendix)
GTEx:Tissue enhanced (pituitary gland)
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in subsets of immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA014520 , CAB002720
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

C5AR1 (HGNC Symbol)

Synonyms

C5A, C5AR, C5R1, CD88

Description

Complement component 5a receptor 1 (HGNC Symbol)

Entrez gene summary

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

47290023 - 47322066

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197405 (version 83.38)

Entrez gene

728

UniProt

P21730 (UniProt - Evidence at protein level)

neXtProt

NX_P21730

Antibodypedia

C5AR1 antibodies

PROTEIN BROWSER

C5AR1-002
C5AR1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C5AR1-002
ENSP00000470613
ENST00000594787
M0QZK7 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
17 aa
1.9 kDa
No 0
C5AR1-003
ENSP00000347197
ENST00000355085
P21730 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 1
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001856 [complement component C5a binding]
GO:0002430 [complement receptor mediated signaling pathway]
GO:0004878 [complement component C5a receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004944 [C5a anaphylatoxin receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007606 [sensory perception of chemical stimulus]
GO:0009986 [cell surface]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016323 [basolateral plasma membrane]
GO:0021534 [cell proliferation in hindbrain]
GO:0030593 [neutrophil chemotaxis]
GO:0031100 [organ regeneration]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0038178 [complement component C5a signaling pathway]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090023 [positive regulation of neutrophil chemotaxis]
Show all
350 aa
39.3 kDa
No 7

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