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Cancer tissues showed weak to moderate cytoplasmic and membranous staining. Few cases of breast and cervix cancers displayed strong cytoplasmic positivity.
Several lymphomas, urothelial and head-neck cancers showed moderate cytoplasmic staining. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
MAP3K5 (HGNC Symbol)
Synonyms
ASK1, MAPKKK5, MEKK5
Description
Mitogen-activated protein kinase kinase kinase 5 (HGNC Symbol)
Entrez gene summary
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Q99683 [Direct mapping] Mitogen-activated protein kinase kinase kinase 5
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0000287 [magnesium ion binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0002931 [response to ischemia] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0007257 [activation of JUN kinase activity] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010941 [regulation of cell death] GO:0016032 [viral process] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0034976 [response to endoplasmic reticulum stress] GO:0038066 [p38MAPK cascade] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043507 [positive regulation of JUN kinase activity] GO:0045087 [innate immune response] GO:0045663 [positive regulation of myoblast differentiation] GO:0046330 [positive regulation of JNK cascade] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070301 [cellular response to hydrogen peroxide] GO:0097190 [apoptotic signaling pathway] GO:0097300 [programmed necrotic cell death] GO:1901216 [positive regulation of neuron death] GO:1902170 [cellular response to reactive nitrogen species] GO:1902911 [protein kinase complex] GO:1990604 [IRE1-TRAF2-ASK1 complex]
