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This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
P04085 [Direct mapping] Platelet-derived growth factor subunit A
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P04085 [Direct mapping] Platelet-derived growth factor subunit A
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0001666 [response to hypoxia] GO:0001775 [cell activation] GO:0001942 [hair follicle development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002576 [platelet degranulation] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0005902 [microvillus] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009611 [response to wounding] GO:0009887 [organ morphogenesis] GO:0009986 [cell surface] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010512 [negative regulation of phosphatidylinositol biosynthetic process] GO:0010544 [negative regulation of platelet activation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014910 [regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0030031 [cell projection assembly] GO:0030036 [actin cytoskeleton organization] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032355 [response to estradiol] GO:0032526 [response to retinoic acid] GO:0032956 [regulation of actin cytoskeleton organization] GO:0035793 [positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043588 [skin development] GO:0045087 [innate immune response] GO:0045740 [positive regulation of DNA replication] GO:0046982 [protein heterodimerization activity] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048286 [lung alveolus development] GO:0048407 [platelet-derived growth factor binding] GO:0048565 [digestive tract development] GO:0048839 [inner ear development] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050919 [negative chemotaxis] GO:0051781 [positive regulation of cell division] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060348 [bone development] GO:0060683 [regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1990401 [embryonic lung development]