Expression of GZMM in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Granzyme M (lymphocyte met-ase 1)

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015624

GENE INFORMATION
Gene name	GZMM (HGNC Symbol)
Synonyms	LMET1, MET1
Description	Granzyme M (lymphocyte met-ase 1) (HGNC Symbol)
Entrez gene summary	Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	544034 - 549924
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197540 (version 83.38)
Entrez gene	3004
UniProt	P51124 (UniProt - Evidence at protein level)
neXtProt	NX_P51124
Antibodypedia	GZMM antibodies

PROTEIN BROWSER

GZMM-001	GZMM-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GZMM-001 ENSP00000264553 ENST00000264553	P51124 [Direct mapping] Granzyme M Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008219 [cell death] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0019835 [cytolysis] GO:0045087 [innate immune response] Show all	257 aa 27.5 kDa	Yes	0
GZMM-002 ENSP00000476255 ENST00000592501	U3KQV5 [Direct mapping] Granzyme M Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	218 aa 23.5 kDa	No	0