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TOPORS

CANCER ATLAS

Gene description

 Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA065661

GENE INFORMATION

Gene name

 TOPORS (HGNC Symbol)

Synonyms

 LUN, RP31, TP53BPL

Description

 Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

Chromosome

 9

Cytoband

 p21.1

Chromosome location (bp)

 32540544 - 32552553

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197579 (version 83.38)

Entrez gene

 10210

UniProt

 Q9NS56 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NS56

Antibodypedia

 TOPORS antibodies

PROTEIN BROWSER
TOPORS-001
TOPORS-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOPORS-001
ENSP00000353735
ENST00000360538
Q9NS56 [Direct mapping]
E3 ubiquitin-protein ligase Topors
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0000930 [gamma-tubulin complex]
GO:0003677 [DNA binding]
GO:0003823 [antigen binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005814 [centriole]
GO:0005868 [cytoplasmic dynein complex]
GO:0006351 [transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010842 [retina layer formation]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030496 [midbody]
GO:0032391 [photoreceptor connecting cilium]
GO:0034504 [protein localization to nucleus]
GO:0035845 [photoreceptor cell outer segment organization]
GO:0036064 [ciliary basal body]
GO:0042127 [regulation of cell proliferation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044547 [DNA topoisomerase binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0046872 [metal ion binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0051457 [maintenance of protein location in nucleus]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 1045 aa
119.2 kDa 		No 0
TOPORS-002
ENSP00000369187
ENST00000379858
Q9NS56 [Direct mapping]
E3 ubiquitin-protein ligase Topors
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000922 [spindle pole]
GO:0000930 [gamma-tubulin complex]
GO:0003677 [DNA binding]
GO:0003823 [antigen binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005814 [centriole]
GO:0005868 [cytoplasmic dynein complex]
GO:0006351 [transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010842 [retina layer formation]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0030496 [midbody]
GO:0032391 [photoreceptor connecting cilium]
GO:0034504 [protein localization to nucleus]
GO:0035845 [photoreceptor cell outer segment organization]
GO:0036064 [ciliary basal body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044547 [DNA topoisomerase binding]
GO:0046548 [retinal rod cell development]
GO:0046549 [retinal cone cell development]
GO:0046872 [metal ion binding]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0051457 [maintenance of protein location in nucleus]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 980 aa
112.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.