Cell atlas - FAR1 - The Human Protein Atlas

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FAR1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Peroxisomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	FAR1
Gene description	Fatty acyl CoA reductase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the peroxisome.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Peroxisomes (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA017322
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the peroxisome.

Main location

Peroxisomes (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017322	A-431	Peroxisomes
	HPA017322	RT4	Peroxisomes

GENE INFORMATION
Gene name	FAR1 (HGNC Symbol)
Synonyms	FLJ22728, MLSTD2, SDR10E1
Description	Fatty acyl CoA reductase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Chromosome	11
Cytoband	p15.3
Chromosome location (bp)	13668670 - 13732346
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197601 (version 83.38)
Entrez gene	84188
UniProt	Q8WVX9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVX9
Antibodypedia	FAR1 antibodies

PROTEIN BROWSER

FAR1-001	FAR1-002	FAR1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAR1-001 ENSP00000346874 ENST00000354817	Q8WVX9 [Direct mapping] Fatty acyl-CoA reductase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005782 [peroxisomal matrix] GO:0008611 [ether lipid biosynthetic process] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0050062 [long-chain-fatty-acyl-CoA reductase activity] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	515 aa 59.4 kDa	No	2
FAR1-002 ENSP00000434624 ENST00000532502	E9PPB8 [Direct mapping] Fatty acyl-CoA reductase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	139 aa 16.9 kDa	No	2
FAR1-006 ENSP00000437111 ENST00000532701	E9PNW8 [Direct mapping] Fatty acyl-CoA reductase 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010025 [wax biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	335 aa 37.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.