Cell atlas - C5orf42 - The Human Protein Atlas

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C5orf42

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	C5orf42
Gene description	Chromosome 5 open reading frame 42
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (SiHa)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036776
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036776	A-431	Cytosol
	HPA036776	SiHa	Cytosol
	HPA036776	U-2 OS	Cytosol

GENE INFORMATION
Gene name	C5orf42 (HGNC Symbol)
Synonyms	FLJ13231, JBTS17
Description	Chromosome 5 open reading frame 42 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has putative coiled-coil domains and may be a transmembrane protein. Defects in this gene are a cause of Joubert syndrome (JBTS). [provided by RefSeq, May 2012]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	37106228 - 37249428
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197603 (version 83.38)
Entrez gene	65250
UniProt	Q9H799 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H799
Antibodypedia	C5orf42 antibodies

PROTEIN BROWSER

C5orf42-001	C5orf42-013	C5orf42-014	C5orf42-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C5orf42-001 ENSP00000421690 ENST00000508244	Q9H799 [Direct mapping] Uncharacterized protein C5orf42 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0042384 [cilium assembly] Show all	3197 aa 361.7 kDa	No	3
C5orf42-013 ENSP00000473657 ENST00000511824	R4GNH6 [Direct mapping] Uncharacterized protein C5orf42 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		496 aa 55.5 kDa	No	0
C5orf42-014 ENSP00000424223 ENST00000514429	H0Y9I8 [Direct mapping] Uncharacterized protein C5orf42 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		2263 aa 255.5 kDa	No	0
C5orf42-201 ENSP00000389014 ENST00000425232	Q9H799 [Direct mapping] Uncharacterized protein C5orf42 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0001822 [kidney development] GO:0003279 [cardiac septum development] GO:0003281 [ventricular septum development] GO:0005515 [protein binding] GO:0007507 [heart development] GO:0016021 [integral component of membrane] GO:0021549 [cerebellum development] GO:0035869 [ciliary transition zone] GO:0042384 [cilium assembly] GO:0042733 [embryonic digit morphogenesis] GO:0060021 [palate development] GO:0060976 [coronary vasculature development] GO:1904491 [protein localization to ciliary transition zone] Show all	3197 aa 361.7 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.